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Science News

Discover the news and inspiring materials from the world of biotechnology.

Many lifesaving biopharmaceuticals are suffering from a slump in venture funding. Novel recombinant protein based therapeutics, but also biosimilars are needed to fill the gaps in unmet patient needs. At Mabion we understand how to advance promising biosimilars and novel biotherapeutics to the clinic and from there to patients. Unfortunately, many promising biopharmaceutical innovations spanning novel recombinant protein therapeutics to biosimilars are being held back in the current, limiting funding climate, depriving patients from access to advanced therapies. Yet the urgency to close gaps in unmet patient care has never been greater. That is why we are launching the “Unlocking the Future of Therapeutics” competition a unique opportunity to support and accelerate biologics development and scale up for an oncology-targeted therapeutic. We are offering €500,000 credit in development services to support an exceptional therapeutic project. This can be a novel therapeutic, but might also be a biosimilar drug which expands patients access to lifesaving care. We have partnered with respected academic experts focused on cancer research to select the most promising candidate.

Mabion Launches €500,000 Services Contest to Support Next-Gen Oncology Breakthroughs

At Mabion we understand how to advance promising biosimilars and novel biotherapeutics to the clinic and from there to patients. Unfortunately, many promising biopharmaceutical innovations spanning novel recombinant protein therapeutics to biosimilars are being held back in the current, limiting funding climate, depriving patients from access to advanced therapies. Yet the urgency to close gaps in unmet patient care has never been greater.That is why we are launching the “Unlocking the Future of Therapeutics” competition a unique opportunity to support and accelerate biologics development and scale up for an oncology-targeted therapeutic.We are offering €500,000 credit in development services to support an exceptional therapeutic project. This can be a novel therapeutic, but might also be a biosimilar drug which expands patients access to lifesaving care.We have partnered with respected academic experts focused on cancer research to select the most promising candidate.

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Modulation of the immune system to treat cancer and on novel approaches to further extend the efficacy of current and emerging immunotherapies led us to our current understanding of the melanoma immune microenvironment in humans and the mechanistic work supporting these observations.

Melanoma Immunotherapy Enhance by Immunity Activation

By reintroducing the Interleukin-4 into IFN-I–dominant, inflammation-deficient tumors, scientists successfully reinvigorated T cell–driven tumor rejection. Whether introduced directly or delivered via engineered T cells in ACT, IL-4 helped reshape the immune landscape, boosting effector T cells and improving survival in mouse models.

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Cumulative incidence of P. falciparum blood-stage infection during a 6-month malaria season (irrespective of symptoms being present) after a single IV infusion of 10 mg kg−1 of CIS43LS (n = 110), 40 mg kg−1 of CIS43LS (n = 110) or placebo (n = 110). P. falciparum infections were detected by 18S qRT–PCR analysis of DBS collected during scheduled trial visits and unscheduled illness visits when malaria was suspected. DBS were collected before the administration of CIS43LS or placebo on day 0 and then on days 1, 3, 7, 14, 21 and 28 and every 2 weeks thereafter for a total of 24 weeks (day 168). Only DBS collected between days 21 and 168 were included. Estimates of the cumulative risk of infection are plotted along with the 95% CIs (shaded areas).

Single-Dose Monoclonal Antibody Therapy Offers Durable Protection Against Malaria

Monoclonal antibody CIS43LS reduced the cumulative incidence of infection by 87.4% at 40 mg/kg during the 6-month qRT-PCR monitoring period. This Phase 2 trial evaluated its efficacy in 330 adults in Mali during a 6-month high-transmission season.CIS43LS is a human IgG1 monoclonal antibody targeting the circumsporozoite protein of Plasmodium falciparum, designed to confer long-acting protection with a single intravenous dose.

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Worldwide preclinical and clinical R&D pipeline activity

Biopharma Drug Development Gaps Strategy

Why biopharma drug development is stalling around just 38 targets? Novel targets decline as biopharma companies favors the familiar ones. Expert report reveals risk-averse shift in biopharma pipeline. Known targets offer efficiency, predictability, and infrastructure. Target crowding threatens innovation in Biopharma Drug Development.

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Mabion - 2025 CDMO Leadership Awards Champion in International Biologics

Winning Trust Through Mabion Biologics CDMO Excellence – exclusive interview with Marty Henehan

What does it take to stand out as a global biologics CDMO? In this interview, Marty Henehan shares insights from DCAT Week, discusses Mabion’s award-winning approach to customer partnerships, and reveals how the company is shaping the future of biologics manufacturing.

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Mabion is a Champion of the 2025 International CDMO Leadership Award in Biologics

Mabion is a Champion of the 2025 International CDMO Leadership Award in Biologics

Mabion Wins as the Champion of the 2025 International CDMO Leadership Award in Biologics! This achievement is a testament to our commitment to innovation, reliability, and excellence in biologics development and manufacturing. We extend our heartfelt thanks to our clients for their trust and collaboration – your success is our success!

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Mabion photo for Contract Pharma Magazine

Mabion’s Fill & Finish services in Contract Pharma Magazine

The Fill & Finish stage of pharma manufacturing may not make headlines, but it is the final crucial step – the point where all the work behind a new drug either comes together or falls apart due to contamination, inefficiencies, or regulatory setbacks. Right now, the demand for high-quality, adaptable fill-finish services is soaring. Mabion Biologics CDMO offer the expertise, flexibility, and advanced technology that pharmaceutical companies need to navigate today’s challenges. Explore our Production Division Manager’s expertise on the role of compliance in today’s filling and finishing landscape in Contract Pharma.

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Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson’s disease patients.

Dyskinesias in Parkinson’s Disease: Promising New Treatment Approach

CPL’36 Phase II clinical trial results reinforce the potential of PDE10A inhibition as a new therapeutic strategy for managing dyskinesias and improving the quality of life for individuals with Parkinson’s disease.

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